Team 9

ChromatIn and transcriptionaL Deregulation in pediatric bone sarcoma

Team leaders : Benjamin Ory et François Lamoureux

Our project

Osteosarcoma (OS) and Ewing Sarcoma (EW) are the most frequent malignant primary bone tumors in children and adolescents, with a mean incidence during the second decade of life. The first line of therapy consists in neoadjuvant poly-chemotherapy, surgical resection followed by adjuvant chemotherapy. Despite improvements in surgical techniques and poly-chemotherapy development, survival rates are still around 70% at 5 years for localized tumors and only 25% for patients with resistance to conventional treatment or metastasis. So far, no clear oncogenic drivers have been identified for OS. Regarding the therapeutic resistance mechanisms, except classical processes like the multidrug resistance phenotype (MDR), no specific mechanisms have been identified as drivers. Therefore, it becomes necessary to explore other possible origins to OS therapeutic resistance and metastatic dissemination studying combinations of unknown transcriptional regulatory circuitries and signaling pathways at the origin of OS development in order to validate innovative therapeutic approaches to improve the medical response of OS.

In this context, we decided to study the implication of chromatin and transcriptional deregulation in metastatic dissemination and resistance development.

We use an association of various in vitro models, in vivo models, PDX, patient samples, single cells and bioinformatics tools.

You can see below our two axis of research

Faculté de Médecine
1 rue Gaston Veil
44 035 Nantes cedex 1 - France
Tel : 02 44 76 91 00 & 02 72 64 11 32
Fax : 02 40 41 28 60 ?
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BET proteins and Super-Enhancers implications in chromatin and transcriptional regulation

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Transcription factor activity and extracellular Stresses ---------------------------------------

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Researchers Benjamin Ory, MCU François Lamoureux, CR Inserm Franck Verrecchia, DR Inserm Françoise Redini, DR Inserm Bénédicte Brounais-Le-Royer, MCU Steven Georges, MCU Marc Baud’huin, MCU-PH Clinicians Vincent Crenn, PH Helios Bertin, MCU-PH Morgane Cleirec, PH

Technical team Régis Brion, IE Rose-Anne Thepault, TR Céline Charrier, TR Séverine Battaglia, IE Jérôme Amiaud, TR Frédéric Jacquot, IE Anaïs Postec, AI Laura Regnier, TN Mathilde Mullard, IE

M2 Thesis

 

National level: SFCE (French Society for Childhood Cancers)

National network React4Kids (basic research on pediatric cancers)

Share4Kids project (labelled by INCa)

Responsible for a work package of the project led by the BoOST-Data consortium (labelled by INCa) aiming at developing specific databases for pediatric tumors

 

2022 :

• publi 1
  • hal :
• publi 2
  • hal :

2021 :

• publi
• publi 2

2020 :

• publi
• publi 2

2019 :

• publi
• publi 2

2018 :

• publi
• publi 2