Team 10 - PETRY

Research Goal

The classical therapeutic scheme for neural cancers, such as Glioblastoma and Neuroblastoma, involved surgery followed with a combination of radio- and chemotherapies. However tumor location and acquired treatment resistance limit the efficacy of these treatments. Novel non-genotoxic therapeutic approaches in combination with actual treatments are currently being explored to improve their efficacy.

On this basis, the PETRY team explores key parameters involved in tumor aggressiveness and relapse, in particular tumor metabolic adaptation and tumor microenvironment cooption.

Our research program is organized around three main axis :
1) The tumor plasticity by deciphering the dynamic evolution of multiple tumor cell states, including molecular subtypes, tumor-stem cells and metabolic heterogeneity
2) The vascular microenvironment and its impact on tumor agressivity and relapse, in particular following radiotherapy/chemotherapy
3) The development of innovative immunotherapeutic strategies through antibody and T-cell engineering

photo equipe

Contact us

We are open to applications from highly motivated individuals.

François Paris, DR INSERM
francois.paris@univ-nantes.fr
Claire Pecqueur, DR CNRS
claire.pecqueur@univ-nantes.fr

Medias

We have shown that GBM are characterized by diverses molecular, cellular and metabolic states, that evolve with time and treatments. We are interested in understanding this dynamic evolution of tumor cells, to subsequently exploit whereas preventing cell states transition or targeting tumor metabolic plasticity could be exploited to reduce GBM aggressiveness or to sensitize them to radio/chemotherapy. How radiation modulate cell state transition and metabolism are also key questions to answer before turning these potential vulnerabilities into therapeutic opportunity.

Vascular dysfunction plays a key role in the enhancement of RT-induced tumor regression and normal tissue toxicity after RT. We recently define that irradiated endothelial cells are developing a different acute and late secretome. We are willing to understand their similarity and difference in the modulation of RT efficacy. Final goal of this project is to facilitate the development of new therapeutic strategies targeting tumor microenvironment to prevent the resistance and recurrence of tumors after RT, which is a major challenge to prolong patient survival

Since 2008, our team focuses on immunotherapeutic strategies targeting the O-acetylated form of GD2 (OAcGD2). Being a carbohydrate antigen, OAcGD2 possesses identical biochemical structures between species, allowing antigen cross-reactivity and is a T cell-independent antigen, an interesting characteristic in poorly immunogenic tumors. We have shown that OAcGD2 is highly expressed on all NB tumors, but, contrary to GD2, is not found on peripheral nerves, pituitary gland and human brain. We have developed the 8B6 anti-OAcGD2 chimeric antibody which display immunological antitumor activity (ADCC and CDC) similar to GD2 mAb in vitro and in vivo. Our recent work has also shown that adoptive transfer of allogeneic Vγ9Vδ2 T lymphocytes might be considered as an efficient immunotherapy, at least in GBM). The final goal of these projects is to establish the proof-of-concept of targeted immunotherapies in preclinical models of GBM, NB and MB in combination with RT, essential for its translation to phase I/II clinical trials.

François Paris, DR INSERM
Claire Pecqueur, DR CNRS

Sophie Fougeray, MCU
Catherine Gratas, MCU-PH
Colin Niaudet, CRCN INSERM
Noémie Joalland, Post-doctorante

Marine Devinat, IE CDD
Laetitia Durand, AI INSERM
Mylene Gaudin, AI CDD
Aline Perrin, T ICO
Elouan Rouméas-Noel, IE CDD

Hortense Alliot,, Doctorante
Léanne Barbarit, Doctorante
Julianne Ceroni, Doctorante
Mélanie Laurent--Blond, Doctorante

Chercheurs associés
Pr. S. Faraj, PU-CHU
Dr. E Rio, PH ICOt
Dr. E. Thébaud, PH ICO

Publications :

2026 :

Niaudet et al. Vascular dysfunctions during radiation retinopathy. Radiother Oncol. 2026

2025 :

Renoult et al. Inhibiting glioblastoma stem cells by targeting pyruvate carboxylase: A novel therapeutic strategy with both opportunities and challenges. Neuro Oncol. 2025. Letter

Perdomo et al. MIRA-1, a p53mut reactivator, is active on Temozolomide-resistant glioblastoma in vitro. Mol Biomed. 2025. Letter

Hirsch et al. Systemic heparin administration impairs lung development in neonatal mice. Sci Rep. 2025. Free PMC article

Jung et al. ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage. Angiogenesis. 2025. Free PMC article

Baldassarre et al. Death-ision: the link between cellular resilience and cancer resistance to treatments. Mol Cancer. 2025. Review

2024 :

Renoult et al.. Metabolic profiling of glioblastoma stem cells reveals pyruvate carboxylase as a critical survival factor and potential therapeutic target. Neuro Oncol. 2024. Free PMC article

Delgado-Rodriguez et al. Automatic classification of normal and abnormal cell division using deep learning. Sci Rep. 2024. PMC article

Desigaux et al. 3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity. Bioactive Materials. 2024. PMC article

Onfray et al. Unraveling hallmark suitability for staging pre- and post-implantation stem cell models. Cell Rep. 2024. Free article

Benichou et al. The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism. Nat Commun. 2024. Free PMC article

Renaud et al. The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis. Commun Biol. 2023. Free PMC article

Guen et al. CRCI2NA inaugural symposium: A meeting on tumor and immune ecosystems. Biol Cell. 2024. Free PMC article

Oliver et al.Transcriptional landscape of the interaction of human Mesenchymal Stem Cells with Glioblastoma in bioprinted co-cultures. Stem Cell Res Ther. 2024. PMC article

Jubelin et al. Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures. Biochim Biophys Acta Mol Cell Res. 2024. Free article

Thomas et al. Arming Vδ2 T Cells with Chimeric Antigen Receptors to Combat Cancer. Clin Cancer Res. 2024. Review

2023 :

Awada et al. Exploiting radiation immunostimulatory effects to improve glioblastoma outcome. Neuro Oncol. 2023. review

Defois et al. Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF. Cell Commun Signal. 2023. Free PMC article.

Rafia et al. The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes. Front Immunol. 2023. Free PMC article

Thomas et al. Targeting pediatric High-Grade Gliomas with OAcGD2-CAR Vδ2 T cells. BioRixv, 2023. Preprint

Gueiderikh et al. Radiation-induced lung injury after breast cancer treatment: incidence in the CANTO-RT cohort and associated clinical and dosimetric risk factors. Front Oncol. 2023. PMC article

Niaudet et al. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. EMBO Mol Med. 2023. Free PMC article

Loussouarn et al. Spatial Distribution of Immune Cells in Primary and Recurrent Glioblastoma: A Small Case Study. Cancers (Basel). 2023. Free PMC article

Oliver et al. A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma. Cancers (Basel). 2023. Free PMC article

Bikfalvi et al. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends Cancer. 2023. Review

Jubelin et al. Three-dimensional in vitro culture models in oncology research. Cell Biosci. 2022. Review

Pu et al. Drug-tolerant persister cells in cancer: the cutting edges and future directions. Nat Rev Clin Oncol. 2023 Nov;20(11):799-813. doi: 10.1038/s41571-023-00815-5. Epub 2023 Sep 25. PMID: 37749382 Free article. Review

2022 :

Bahri et al. SIRPα-specific monoclonal antibody enables antibody-dependent phagocytosis of neuroblastoma cells. Cancer Immunol Immunother. 2022. PMC article

Dusserre et al. Microvalve bioprinting as a biofabrication tool to decipher tumor and endothelial cell crosstalk: application to a simplified glioblastoma model. Bioprinting. 2022. PMC article

Alzial et al. Wild-type Isocitrate dehydrogenase under the potlight of glioblastoma. Oncogene. 2022. Review

Ghannam et al. Impact of radiation therapy on fatigue at 1 year in breast cancer survivors in the prospective multicentre CANcer TOxicity cohort. Eur J Cancer. 2022. Multicenter study

Rabé et al. Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment. Front Cell Dev Biol. 2022. Free PMC article

Allali et al. CANTO-RT: Skin toxicities evaluation of a multicentre large prospective cohort of irradiated patients for early-stage breast cancer. Int J Cancer. 2022. Multicenter study

Doan Ngoc et al. Effector Memory-Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses. J Am Soc Nephrol. 2022. Free PMC article

Sancerni et al. UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling. Front Immunol. 2022. Free PMC article

Combot et al. Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes. Cell Rep. 2022. Free article

Kuo Aet al. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022. Free PMC article

Garnier et al. The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p. Biomedicines. 2022. Free PMC article

Lalier et al. Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death. Biomolecules. 2022.. Review

2021 :

Degorre et al. Mechanistic insights of radiation-induced endothelial senescence impelling glioblastoma genomic instability at relapse. BioRixv, 2021. Preprint

Tilly et al. Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells. Front Immunol. 2021. Free PMC article

Sosa-Marrero et al. Towards a reduced in silico model predicting biochemical recurrence after radiotherapy in prostate cancer. IEEE Transactions on Biomedical Engineering. 2021. PMC article

Poczobutt et al. Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. Am J Respir Cell Mol Biol. 2021. PMC article

Foucault et al. Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition. Cancers (Basel). Free PMC article

Almeida et al. Treatment-induced shrinking of tumour aggregates: a nonlinear volume-filling chemotactic approach. J Math Biol. 2021. Article

Terrié et al. Store-Operated Calcium Channels Control Proliferation and Self-Renewal of Cancer Stem Cells from Glioblastoma. Cancers (Basel). 2021. Free PMC article

Lalier et al. TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. Cell Death Dis. 2021. Free PMC article

2020 :

Leonetti et al. Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation-induced intestinal toxicity. 2020. Cancer Res. 2020. PMC article

Fleurence et al. Impairing Temozolomide Resistance Driven by Glioma Stem-Like Cells With Adjuvant Immunotherapy Targeting O-acetyl GD2 Ganglioside. Int. J. Cancer. 2020. PMC article

Oizel et al. Glutamine uptake and utilization of human mesenchymal Glioblastoma in orthotopic mouse model. Cancer & Metabolism 2020. PMC article

Ketteler et al Caveolin 1 regulates the ASMase/ ceramide-mediated radiation-response of endothelial cells in the context of tumor-stroma-interactions. Cell Death Dis. 2020. Article

Potiron et al. Tumor Vasculature Remodeling by Radiation Therapy Increases Doxorubicin Distribution and Efficacy. Cancer Lett. 2020. Article

Clément-Colmou et al. Influence of Radiotherapy Fractionation Schedule on the Tumor Vascular Microenvironment in Prostate and Lung Cancer Models. Cancers. 2020.

Dufresne et al. Exercise training improves radiotherapy efficiency in a murine model of prostate cancer. FASEB J 2020.

Rabé et al. Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma. Cell Death Dis. 2020. Article

Mignard et al. Sphingolipids Distribution at Mitochondria-Associated Membranes (MAM) Upon Induction of Apoptosis. 2020. J Lipid Res. 2020. Article

Pérez-García et al. Universal scaling laws rule explosive growth in human cancers. Nat Phys. 2020. Free PMC article.

Guyon et al. Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells. Cell Death Dis. 2020. Free PMC article

Pariset et al. 53BP1 Repair Kinetics for Prediction of In Vivo Radiation Susceptibility in 15 Mouse Strains. Radiat Res. 2020.

Yanagida et al. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020. Free PMC article.

Salaud et al. Mitochondria transfer from tumor-activated stromal cells (TASC) to primary Glioblastoma cells Biochem Biophys Res Commun. 2020

Briand et al. N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool. Mol Ther Nucleic Acids. 2020. Free PMC article

Briand et al. Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity. Epigenomics. 2020

Cheray et al. Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme. Mol Cancer. 2020. Free PMC article

Averbeck et al. Establishing Mechanisms Affecting the Individual Response to Ionizing Radiation. Int J Radiat Biol. 2020

Prasanna et al. Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. JNCI. 2020

Oliver et al. Drug resistance in glioblastoma: are persisters the key to therapy? Cancer Drug Resist. 2020. Review

Duforestel et al. Cell-free circulating epimarks in cancer monitoring. Epigenomics. 2020. Review

Thomas et al. CAR T Cell Therapy's Potential for Pediatric Brain Tumors. Cancers (Basel). 2021. Review

Olivier et al. Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress. Front Mol Biosci. 2021. Review

If you are interested in joining the team, please feel free to submit your spontaneous applications to us.

Institutions :

Funding :

Associations :

Updated on 28 April 2026.