Team 12
MITIC, Manipulation of Lymphocytes for Immunotherapy
Team Leader: Emmanuel Scotet
The results obtained in these different domains enabled Team MITIC to position itself, both nationally and internationally, as an important player in fundamental and applied immunology research in the field of lymphoid population biology and their exploitation in immunotherapies. This recognition is reflected by: (i) its membership in many national collaborative programs funded, some of them in portage (ii) the direction, the management or the membership in various consortia or structures at the local or national level, (iii) co-leadership and participation in national and international thematic networks. These activities are carried out in collaboration with numerous groups/institutes at the local, national and international levels. This recognition is also illustrated by the involvement of many members of the team not only in university teaching activities and in the organization of conferences but also their participation in expertise activities or consultancy. Concerning knowledge transfer, the team is developing a growing number of industrial partnerships or clinical partnerships, which also allow it to finance and valorize its research activities.
Selected Publications 2017 - 2022
Makanga DR, Jullien M, David G, Legrand N, Willem C, Dubreuil L, Walencik A, Touzeau C, Gastinne T, Tessoulin B, Le Gouill S, Mahé B, Gagne K, Chevallier P, Clemenceau B, Retière C. 2022. Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response. Oncoimmunology. 14;10(1):1936392. doi: 10.1080/2162402X.2021.1936392.
Harly C, Joyce SP, Domblides C, Bachelet T, Pitard V, Mannat C, Pappalardo A, Couzi L, Netzer S, Massara L, Obre E, Hawchar O, Lartigue L, Claverol S, Cano C, Moreau JF, Mahouche I, Soubeyran I, Rossignol R, Viollet B, Willcox CR, Mohammed F, Willcox BE, Faustin B, Déchanet-Merville J. 2021. Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2. Sci Immunol. 6(61):eaba9010. doi: 10.1126/sciimmunol.aba9010.
Rafia C, Harly C, Scotet E. 2020. Beyond CAR T cells: engineered Vγ9Vδ2 T cells to fight solid tumors. Immunol Rev. 298:117-133. doi: 10.1111/imr.12920.
Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. 2020. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 50(10):1454-1467. doi: 10.1002/eji.201948416.
Makanga DR, Guillaume T, Willem C, Legrand N, Gagne K, Cesbron A, Gendzekhadze K, Peterlin P, Garnier A, Le Bourgeois A, Béné MC, Chevallier P, Retière C. 2020. PTCY and ATG versus PTCY as GVHD prophylaxis for peripheral blood stem cells haploidentical transplants: comparison of T-cell and NK effectors reconstitution. J Immunol. 205(5):1441-1448. doi: 10.4049/jimmunol.2000578.
Dustin ML, Scotet E, Olive D. 2019. An X-ray Vision for Phosphoantigen Recognition. Immunity. 50(4):1026-1028. doi: 10.1016/j.immuni.2019.03.015.
Devilder MC, Moyon M, Gautreau L, Navet B, Perroteau J, Delbos F, Gesnel MC, Breathnach R, Saulquin X. 2019. Ex vivo Evolution of Human Antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies. BMC Biotechnol. 19(1):14. doi: 10.1186/s12896-019-0504-z.
Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A. 2019. The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat Immunol. 20(9):1150-1160. doi: 10.1038/s41590-019-0445-7.
Chauvin C, Joalland N, Perroteau J, Jarry U, Lafrance L, Willem C, Retière C, Oliver L, Gratas C, Gautreau-Rolland L, Saulquin X, Vallette FM, Vié H, Scotet E, Pecqueur C. 2019. NKG2D controls natural reactivity of Vγ9Vδ2 T lymphocytes against mesenchymal glioblastoma cells. Clin Cancer Res. 25(23):7218-7228. doi: 10.1158/1078-0432.CCR-19-0375.
Willem C, Makanga DR, Guillaume T, Maniangou B, Legrand N, Gagne K,Peterlin P, Garnier A, Béné MC,Cesbron A, Le Bourgeois A, Chevallier P* and Retiere C*. 2019. Impact of KIR/HLA Incompatibilities on NK Cell Reconstitution and Clinical Outcome after T Cell–Replete Haploidentical Hematopoietic Stem Cell Transplantation with Posttransplant Cyclophosphamide. J Immunol. 202(7):2141-2152. doi: 10.4049/jimmunol.1801489.
Quémémer A, Morisseau S, Sousa RP, Trillet K, Maillasson M, Leray I, Jacques Y, Dion J, Barbieux I, Frutoso M, Laurent AD, Le Questel JY, Mortier E. 2019. IL-15Ra membrane-anchorage either in cis or trans is required for stabilization of IL-15 and optimal signaling. J. Cell. Sci. 133(5):jcs236802. doi: 10.1242/jcs.236802.
Frutoso M., Morisseau S., Tamzalit F., Leray I., Quéméner A., Jacques Y., and Mortier E. 2018. Critical role of CD8 T cells on NK cell responsiveness to cytokine re-stimulation in vivo. J Immunol. 201(2): 493-506. doi: 10.4049/jimmunol.1800086.
Ollier J, Vivien R, Vié H, Clémenceau B. 2017. Transfection of FcγRIIIa (CD16) Alone Can Be Sufficient To Enable Human αβTCR T Lymphocytes To Mediate Antibody-Dependent Cellular Cytotoxicity. ImmunoHorizons. 1(5) 63-70. doi.org/10.4049/immunohorizons.1700022.
Quéméner A, Maillasson M, Arzel L, Sicard B, Vomiandry R, Mortier E, Dubreuil D, Jacques Y, Lebreton J, Mathe M. 2017. Discovery of a Small-Molecule Inhibitor of IL-15: Pharmacophore-Based Virtual Screening and Hit Optimization. J. Med. Chem. 60(14):6249-6272. doi: 10.1021/acs.jmedchem.7b00485.
Ouisse LH, Gautreau-Rolland L, Devilder MC, Osborn M, Moyon M, Visentin J, Halary F, Bruggemann M, Buelow R, Anegon I, Saulquin X. 2017. Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies. BMC Biotechnol. 17(1):3. doi: 10.1186/s12896-016-0322-5.
Jarry U, Chauvin C, Joalland N, Léger A, Minault S, Robard M, Bonneville M, Oliver L, Vallette FM, Vié H, Pecqueur C, Scotet E. 2016. Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors. Oncoimmunology. 5(6):e1168554. doi: 10.1080/2162402X.2016.1168554.
Hesnard L, Legoux F, Gautreau L, Moyon M, Baron O, Devilder MC, Bonneville M, Saulquin X. 2016. Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus. Eur J Immunol. (3):560-569. doi: 10.1002/eji.201545951.
Clémenceau B, Valsesia-Wittmann S, Jallas AC, Vivien R, Rousseau R, Marabelle A, Caux C, Vié H. 2015. In Vitro and In Vivo Comparison of Lymphocytes Transduced with a Human CD16 or with a Chimeric Antigen Receptor Reveals Potential Off-Target Interactions due to the IgG2 CH2-CH3 CAR-Spacer. J Immunol Res. 2015:482089. doi: 10.1155/2015/482089.
Partners
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Fundings
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Team Members
Researchers
Emmanuel Scotet, DR Inserm
Christelle Retière, DR EFS
Erwan Mortier, DR CNRS
Xavier Saulquin, PU
Christelle Harly, CR CNRS
Katia Gagne, CR EFS
Laetitia Gautreau, MCU
Fabienne Konczak-Del Gatto, MCU
Nina Belaid, ATER
Technical and Administrative Staff
Marie-Claire Devilder, IR CHU
Agnès Quéméner, IR Inserm
Béatrice Clémenceau, IR CHU
Sabine Sévère, IR ONIRIS
Mike Maillasson, IR Inserm
Delphine Coulais, IE Inserm
Raoudha Fadhloun, IE CDD Inserm
Nolwenn Legrand, TCH EFS
Gaëlle David-Bosquaux, TCH EFS
Catherine Willem, TCH EFS
Jocelyn Ollier, IE CHU
Aurélie Domène, IE CDD Université (STC)
Guiet Elodie, AI Inserm (STC)
Clinicians
Patrice Chevallier, PU-PH
Marie-Christine Béné, PU-PH
Thierry Guillaume, PH
PhD Students and Post-Docs
Audrey Grain, PhD student
Enora Ferron, PhD student
Morgane Chauvet, PhD student
Joseph Léger, PhD student
Perla Salameh, PhD student
Pierre Machy, PhD student
Maxime Julien, PhD student
News
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Audrey Grain, doctorante au sein de l’équipe 12, participera à la soirée annuelle de la Fondation Groupama, dans le cadre du financement de sa thèse. Elle présentera ses travaux, sur la recherche de nouvelles cibles antigéniques dans les leucémies aigües lymphoblastiques de l'enfant et l'analyse de la sensibilité à la lyse. Sa présentation de 3 min aura lieu le 23 Février à partir de 18h30! Vous pouvez bien sur participer à la soirée via les liens suivants: connexion Teams et page sur le site internet
5€ par participant seront reversés à l’association Huntington !