Our research aims to develop diagnostic and therapeutic tools to fight cancer by focusing on the delivery of radionuclides to cancer cells and their biological effects.


Research Axes



Fundings/Networks

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Platforms



Plateau technique de radioactivité


 

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Latest publications

Research Projects

With the identification of numerous relevant biomarkers, nuclear medicine offers innovative approaches for precision therapeutics and theranostics in oncology, using radiolabeled antibodies or other vectors. Our team gathers working groups with all the competences required to design new radiopharmaceuticals and validate them from preclinical to clinical evaluations, especially immuno-PET and targeted radionuclide therapy (TRT), especially using alpha emitters. This translational research requires a pluridisciplinary expertise going from the extraction of the radionuclides to the preparation of the radiopharmaceuticals.

Originally investigating radiolabeled antibodies to treat cancer and hemopathies, over the past 5 years we have been moving forward to developing a research in molecular imaging, especially PET, innovative PET emitters being now available for imaging tumor phenotype, in particular with radiolabeled mAbs (immuno-PET) through theranostic approaches. Biomarker imaging using immuno-PET represents also a promising tool to predict efficacy of targeted therapies (precision therapeutics based on predictive imaging or companion diagnostic) or to predict patient outcome (prognostic imaging and radiomics). Development of radiopharmaceuticals relies on a fundamental and forward thinking on radionuclides, targets, new vectors and requires to develop pertinent animal models (murine, canine) before clinical development, but also requires expertise in quantitative imaging. Each specific field including radiopharmacy, chemistry/radiochemistry, radiobiology and immunology is developing its own work and projects towards a common goal. Our pluridisciplinary research is integrated in the personalized/stratified medicine, tumor targeting with innovative α, β- and β+ radionuclides allowing a predictive whole-body imaging which is complementary to metabolic (PET using FDG) and morphologic (CT and MRI) imaging as well as image guided innovative targeted therapies (quantitative imaging, dosimetry, radiomics).

Team members

 

Research Scientists / Lecturers

Michel Chérel - PU/PH
Françoise Kraeber-Bodéré - PU/PH

Mathilde Allard - MCU
Clément Bailly - MCU-PH
Caroline Bodet-Milin - PU-PH
Mickael Bourgeois - MCU-PH
Thomas Carlier - PH
Nicolas Chouin - MCU
Alain Faivre-Chauvet - PU-PH
Joëlle Gaschet - MCU
Jean-François Gestin - DR Inserm
François Guérard - CR CNRS
Yannick Guilloux - PU
Catherine Ibish - MCU
Marie Mougin-Degraef - MCU-PH
Latifa Rbah-Vidal - MCU
Caroline Rousseau - MCU-PH
Simon Stute - IR

Research assistants

Frédérique Adolphe - AI
Cyrille Alliot - IR
Catherine Chauvet - TR
Romain Eychenne - IR
Marie-Hélène Gaugler - IR
Sébastien Gouard - IE
Patricia Le Saec - IE
Françoise Leost - IR
Romain Oger - AI
Séverine Marionneau-Lambot - IR
Gauthier Frécon - IE

Clinical research physician

Catherine Ansquer -PH
Jean-Marc Classe - PU-PH
Ludovic Ferrer - PH
Eric Frampas - PH
Hatem Nécib - PH
Pierre Peterlin - PH
Yann Touchefeu - PH
Nicolas Varmenot - PH 


Post-docs

Khac Lan Nguyen
Nasrin Taheri
Clémence Maingueneau

PhD students

Arthur David
Nour El Ayoubi
Jade Fantin
Romain Fouinneteau
Charlotte Jacquet
Ludovic Le Saux
Mehdi Latif
Nina Laurent
Mathilde Ligeour
Alexandre Lugat
Alexandre Merasli
Cassandra Métivier
Max Celio Nzatsi Nzatsi
Loris Roncali
Mylène Sorin
 
Nuclear Oncology Team, June 2022


Job offers

Coming soon !

Selected Publications

  • Perrin J, Capitao M, Allard M , Chouin N , Gouard S, Marionneau-Lambot S, Louvet C, Donnadieu E, Bruchertseifer F, Morgenstern A, Chérel M, Gaschet J, Guilloux Y. Targeted alpha particle therapy remodels the tumor microenvironment and improves efficacy of immunotherapy. Int J Radiat Oncol Biol Phys. 2022;112(3):790-801. doi: 10.1016/j.ijrobp.2021.10.013.
  • Maingueneau C, Berdal M, Eychenne R, Gaschet J, Chérel M, Gestin JF, Guérard F. 211At and 125I-Labeling of (Hetero)Aryliodonium Ylides: Astatine Wins Again. Chemistry. 2022;28(11):e202104169. doi: 10.1002/chem.202104169.
  • Alberge JB, Kraeber-Bodéré F, Jamet B, Touzeau C, Caillon H, Wuilleme S, Avet-Loiseau H, Corre J, Magrangeas F, Carlier T, Bodet-Milin C, Chérel M, Moreau P, Minvielle S, Bailly C. Molecular signature of FDG-PET biomarkers in newly diagnosed multiple myeloma patients: a genome-wide transcriptome analysis from the CASSIOPET study. J Nucl Med. 2022 Jan 27:jnumed.121.262884. doi: 10.2967/jnumed.121.262884. [Online ahead of print]
  • Delage JA, Gnesin S, Prior JO, Barbet J, Le Saëc P, Marionneau-Lambot S, Gouard S, Chérel M, Bourgeois M, Schaefer N, Viertl D, Fierle JK, Dunn SM, Faivre-Chauvet A. Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety. Cancers. 2021;13(23):5936. doi: 10.3390/cancers13235936.
  • Bodet-Milin C, Faivre-Chauvet A, Carlier T, Ansquer C, Rauscher A, Frampas E, Toulgoat F, Masson D, Bourgeois M, Cerato E, Rohmer V, Couturier O, Drui D, Goldenberg DM, Sharkey RM, Barbet J, Kraeber-Bodere F. Anti-CEA pretargeted Immuno-PET shows higher sensitivity than DOPA-PET/CT to detect relapsing metastatic medullary thyroid carcinoma: Post- hoc analysis of the iPET-MTC study. J Nucl Med. 2021;62(9):1221-1227. doi: 10.2967/jnumed.120.252791.
  • Guérard F, Maingueneau C, Liu L, Eychenne R, Gestin JF, Montavon G, and Galland N. Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals. Acc. Chem. Res. 2021, 54, 3264−3275. doi: 10.1021/acs.accounts.1c00327.
  • Jamet B, Morvan L, Nanni C, Michaud AV, Bailly C, Chauvie S, Moreau P, Touzeau C, Zamagni E, Bodet-Milin C, Kraeber-Bodéré F, Mateus D, Carlier T. Random survival forest to predict transplant-eligible newly diagnosed multiple myeloma outcome including FDG-PET radiomics: a combined analysis of two independent prospective European trials. Eur J Nucl Med Mol Imaging. 2021;48(4):1005-1015. doi: 10.1007/s00259-020-05049-6.
  • Capitao M, Perrin J, Simon S, Gouard S, Chouin N, Bruchertseifer F, Morgenstern A, Rbah‐Vidal L, Chérel M, Scotet E, Labarrière N, Guilloux Y and Gaschet J. Anti‐Tumor Efficacy of PD‐L1 Targeted Alpha‐Particle Therapy in a Human Melanoma Xenograft Model. Cancers. 2021;13(6):1256. doi: 10.3390/cancers13061256.
  • Touchefeu Y, Bailly C, Frampas E, Eugène T, Rousseau C, Bourgeois M, Bossard C, Faivre-Chauvet A, Rauscher A, Masson D, David A, Cerato E, Carlier T, Sharkey RM, Goldenberg DM, Barbet J, Kraeber-Bodere F, Bodet-Milin C. Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer metastases: a pilot study. Eur J Nucl Med Mol Imaging. 2021;48(3):874-882. doi: 10.1007/s00259-020-04989-3.
  • Berdal M, Gouard S, Eychenne R, Marionneau-Lambot S, Croyal M, Faivre-Chauvet A, Chérel M, Gaschet J, Gestin JF and Guérard F. Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies. Chem. Sci. 2021;12(4):1458. DOI: 10.1039/d0sc05191h.
  • Grémy O, Mougin-Degraef M, Devilliers K, Berdal M, Laroche P, Miccoli L.  DTPA-Coated Liposomes as a New Delivery Vehicle for Plutonium Decorporation.  Radiat Res 2021;195(1):77-92.  doi: 10.1667/RADE-20-00142.1.
  • Zamagni E, Nanni C, Dozza L, Carlier T, Bailly C, Tacchetti P, Versari A, Chauvie S, Gallamini A, Gamberi B, Caillot D, Patriarca F, Macro M, Boccadoro M, Garderet L, Barbato S, Fanti S, Perrot A, Gay F, Sonneveld P, Karlin L, Cavo M, Bodet-Milin C, Moreau P, Kraeber-Bodéré F. Standardization of 18F-FDG-PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma. J Clin Oncol. 2021;39(2):116-125. doi: 10.1200/JCO.20.00386.
  • Millardet M, Moussaoui S, Mateus D, Idier J, Carlier T. Local-mean preserving post-processing step for non-negativity enforcement in PET imaging: application to 90Y-PET. IEEE Trans Med Imaging. 2020;39(11):3725-3736. doi: 10.1109/TMI.2020.3003428.
  • Gouard S, Maurel C, Marionneau-Lambot S , Dansette D, Bailly C, Guérard F, Chouin N, Haddad F, Alliot C, Gaschet J, Eychenne R, Kraeber-Bodéré F and Chérel M. Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease. Cancers 2020; 12, 2721; doi:10.3390/cancers12092721.
  • Ansquer C, Drui D, Mirallié E, Renaudin-Autain K, Denis A, Gimenez-Roqueplo AP, Leux C, Toulgoat F, Kraeber-Bodéré F, Carlier T. Usefulness of FDG-PET/CT-Based Radiomics for the Characterization and Genetic Orientation of Pheochromocytomas Before Surgery. Cancers. 2020;12(9):E2424. doi: 10.3390/cancers12092424.
  • Touchefeu Y, Bailly C, Frampas E, Eugène T, Rousseau C, Bourgeois M, Bossard C, Faivre-Chauvet A, Rauscher A, Masson D, David A, Cerato E, Carlier T, Sharkey RM, Goldenberg DM, Barbet J, Kraeber-Bodéré F, Bodet-Milin C. Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer metastases: a pilot study. Eur J Nucl Med Mol Imaging. 2020;48:874. doi: 10.1007/s00259-020-04989-3.
  • Rousseau C, Goldenberg DM, Colombie M, Sebille JC, Meingan P, Ferrer L, Baumgartner P, Cerato E, Masson D, Campone M, Rauscher A, Fleury V, Labbe C, Faivre-Chauvet A, Frenel JS, Toquet C, Barbet J, Sharkey RM, Campion L, Kraeber-Bodéré F. Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer. J Nucl Med. 2020;61(8):1205-1211. doi: 10.2967/jnumed.119.236000.
  • Bailly C, Carlier T, Berriolo-Riedinger A, Casasnovas O, Gyan E, Meignan M, Moreau A, Burroni B, Djaileb L, Gressin R, Devillers A, Lamy T, Thieblemont C, Hermine O, Kraeber-Bodéré F, Le Gouill S, Bodet-Milin C. Prognostic value of FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project. Haematologica. 2020;105(1):e33-e36. doi: 10.3324/haematol.2019.223016.
  • Vidal A, Bourdeau C, Frindel M, Garcia T, Haddad F, Faivre-Chauvet A, and Bourgeois M. ARRONAX Cyclotron: Setting up of In-House Hospital Radiopharmacy. BioMed Research International Volume 2020, Article ID 1572841, 6 pages https://doi.org/10.1155/2020/1572841.
  • Navarro AS, LE Bihan T, Le Saec P, Le Bris N, Bailly C, Sai-Morel C, Bourgeois M, Chérel M, Tripier R, Faivre-Chauvet A. TE1PA as innovating chelator for 64Cu immuno-TEP imaging: a comparative in vivo study with DOTA/NOTA by conjugation on 9E7.4 mAb in a syngeneic multiple myeloma model. Bioconjug Chem. 2019;30(9):2393-2403. doi: 10.1021/acs.bioconjchem.9b00510.
  • Bailly C, Gouard S, Guérard F, Chalopin B, Carlier T, Faivre-Chauvet A, Remaud-Le Saëc P, Bourgeois M, Chouin N, Rbah-Vidal L, Tripier R, Haddad F, Kraeber-Bodéré F, Bodet-Milin C, Chérel M. What is the Best Radionuclide for Immuno-PET of Multiple Myeloma? A Comparison Study Between 89Zr- and 64Cu-Labeled Anti-CD138 in a Preclinical Syngeneic Model. Int J Mol Sci. 2019;20(10):E2564. doi: 10.3390/ijms20102564.