• Le 12 mai 2022
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Webinar by Dr. Gaetano Gargiulo

Glioblastoma is heterogeneous and incurable. We have recently developed a technology to design synthetic reporters that reflect the transcriptional output of tumor cell states and signaling pathway activity. This method is generally applicable to study homeostasis in normal tissues and diseases. Using our published data, I will discuss our findings in glioblastoma, where synthetic gene tracing establishes a causal link between cellular and molecular heterogeneity and therapeutic responses. From our unpublished data, I will show our novel method of designing synthetic locus control regions for any cellular entity or condition of interest, and present successful examples.